As a distributor of Twist Bioscience’s Synthetic Biology (SynBio) portfolio, we offer a comprehensive suite of high-quality, scalable, and cost-effective DNA and antibody products designed to accelerate research and innovation across various industries. Twist Bioscience’s proprietary silicon-based DNA synthesis platform revolutionizes synthetic biology by delivering unparalleled precision and throughput.
Twist Bioscience provides rapid and accurate gene synthesis services, enabling researchers to accelerate their discoveries. The platform offers:
Gene Fragments: Linear DNA sequences ranging from 300 bp to 5 kb, ideal for cloning and assembly applications.
Clonal Genes: Sequence-verified genes cloned into vectors, ensuring high fidelity and ready-to-use constructs.
Express Genes: Rapid turnaround service delivering clonal genes in as few as 4 days, facilitating time-sensitive projects.
These offerings are designed to meet the diverse needs of synthetic biology applications, from basic research to industrial biotechnology.
Twist Bioscience’s Oligo Pools are highly diverse collections of single-stranded DNA oligonucleotides synthesized using their proprietary silicon-based DNA writing technology. This platform enables the massively parallel production of hundreds of thousands of high-quality, accurate oligos per run, facilitating the generation of complex and diverse oligo pools for various applications.
Oligo Length: Up to 300 nucleotides
Pool Size: No limits on pool size
Yield: 0.2 fmol average per oligo
Uniformity: 90% of oligos represented within less than 2.0x of the mean
Error Rate: Up to 1:3000
These oligo pools are ideal for applications such as CRISPR screening, massively parallel reporter assays (MPRAs), and other high-throughput experiments requiring precise and uniform oligonucleotide synthesis.
For researchers requiring cloned oligo pools, Twist Bioscience offers an optimized cloning service that synthesizes, amplifies, and clones user-designed oligo pool libraries. This service ensures high uniformity and low error rates, with chimera rates as low as 1.5%. Turnaround times range from 4 to 8 weeks, depending on the oligo length and vector requirements.
Twist Bioscience’s variant libraries are tailored to support protein engineering, antibody discovery, and functional genomics. Utilizing high-fidelity oligo synthesis, the platform enables the creation of:
Combinatorial Variant Libraries: Comprehensive libraries covering vast sequence space for directed evolution studies.
Site Saturation Libraries: Focused libraries targeting specific residues for deep mutational scanning.
TCR Libraries: Diverse T-cell receptor libraries for immunotherapy research.
These libraries are synthesized with precision, ensuring each variant is accurately represented.
Twist Bioscience’s antibody discovery platform combines synthetic biology with computational tools to expedite therapeutic development:
Synthetic Antibody Libraries: Pre-constructed and validated libraries for rapid screening.
Antibody Optimization: Services including affinity maturation and humanization to enhance antibody properties.
These solutions streamline the path from discovery to clinical candidate.